Installing pharmaceutical water purification equipment involves a structured process to ensure regulatory compliance, system integrity, and product water quality. Below is a professional step-by-step guide tailored for pharmaceutical-grade systems like Purified Water (PW), Water for Injection (WFI), or Pure Steam Generators:

✅ Installation Steps for Pharmaceutical Water Purification Equipment
1. Site Preparation
Confirm URS (User Requirement Specification) and approved layout drawings.

Ensure availability of:

Clean room or classified area (if required).

Proper floor drainage and load-bearing structure.

Power supply, water inlet/outlet piping, and space for maintenance.

2. Unpacking & Inspection
Check equipment and accessories against packing list.

Inspect for transit damage.

Record serial numbers and equipment labels for validation.

3. Mechanical Installation
Anchor the system: Secure frame and base to the floor.

Connect piping:

Feed water inlet

Product water outlet

Reject water line

CIP/SIP lines if required

Use sanitary-grade piping (e.g., 316L stainless steel, orbital welded).

Maintain 3D dead-leg rules and slope for drainability.

Install pressure gauges, flow meters, and sampling points.

4. Electrical Installation
Connect to main power supply through a control panel.

Ensure earthing/grounding is in place.

Wire all instrumentation, sensors (TOC, conductivity, level), and control systems.

Configure PLC/HMI if automated.

5. Utility Connections
Connect:

Compressed air (for valves, if pneumatic)

Steam (for pure steam generator or SIP)

Cooling water (for multi-effect distiller)

6. Initial Cleaning & Sanitization
Flush the system with clean water to remove debris.

Perform chemical cleaning or passivation for stainless steel surfaces.

Sanitization using hot water, steam, or chemical agents (e.g., NaOH, H₂O₂).

7. Commissioning
Perform dry run to check pumps, valves, sensors, alarms, and control logic.

Operate with water to ensure:

Flow rates and pressure are as per design.

No leaks, vibration, or abnormal noise.

Verify instrument calibration.

8. Validation Support
IQ (Installation Qualification): Document installation conformity.

OQ (Operational Qualification): Test operating conditions.

PQ (Performance Qualification): Validate water quality and system performance.

9. Training & Handover
Train the client team on:

Start-up and shutdown procedures

Routine maintenance

Alarm handling

Provide as-built drawings, manuals, certificates, and validation documents.